出汗不良症，汗疱疹。
水疱性掌跖皮炎
特发性过敏性接触性皮炎、遗传过敏、或对感染如浅部皮肤真菌病的反应（这时称为自体敏感）。与汗腺活动性和功能障碍无关；因此历史上的术语可能引起误导。
掌跖部位可见瘙痒性、深在充满液体的水疱，之后伴有脱屑（称干燥层板状出汗不良症）。病人通常描述瘙痒为首发症状，接着出现水疱，最后出现红斑。
表皮内海绵状水肿性水疱。
取决于病因，特发性和特应性通常慢性复发。
继发感染和过敏性接触性皮炎。
依据典型临床特征。与特应性皮炎鉴别：寻找遗传过敏特征，做点刺试验。
外用糖皮质激素，有时需短疗程系统性应用；杀菌剂湿敷，单宁酸沐浴，外用氯碘羟喹氧化锌油或钙依赖磷酸酶拮抗剂。
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